Assay Detail
Binding
CHEMBL3117736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human dopamine D3 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
28
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.02 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2106804 | NAXAGOLIDE HYDROCHLORIDE | -1.0 | 2 | 9.00 |
| CHEMBL3115576 | — | — | 2 | 8.78 |
| CHEMBL538542 | — | — | 2 | 8.74 |
| CHEMBL3115575 | — | — | 2 | 8.54 |
| CHEMBL134807 | — | — | 2 | 8.50 |
| CHEMBL3115574 | — | — | 2 | 8.25 |
| CHEMBL3115582 | — | — | 2 | 8.06 |
| CHEMBL3115579 | — | — | 2 | 8.04 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | 4.0 | 2 | 7.90 |
| CHEMBL3115585 | — | — | 2 | 7.72 |
| CHEMBL3115578 | — | — | 2 | 7.66 |
| CHEMBL3115577 | — | — | 2 | 7.62 |
| CHEMBL3115580 | — | — | 2 | 7.49 |
| CHEMBL3115581 | — | — | 2 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2106804 | NAXAGOLIDE HYDROCHLORIDE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2106804 | NAXAGOLIDE HYDROCHLORIDE | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL3115576 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL3115576 | — | Ki | = | 1.79 | nM | 8.75 |
| CHEMBL538542 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL538542 | — | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL3115575 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL134807 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL134807 | — | Ki | = | 3.18 | nM | 8.50 |
| CHEMBL3115574 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL3115575 | — | Ki | = | 7.87 | nM | 8.10 |
| CHEMBL3115582 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL3115579 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL3115582 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3115579 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL3115574 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL3115585 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL3115578 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL3115578 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3115577 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL3115577 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL3115580 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL3115580 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3115581 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL3115581 | — | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL3115585 | — | Ki | = | 547.0 | nM | 6.26 |