Assay Detail
Binding
CHEMBL3117967
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Inhibition of human recombinant MAO-A assessed as kynuramine oxidation to 4-hydroxyquinoline after 40 mins by LC-MS/MS analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel series of 6-substituted 3-(pyrrolidin-1-ylmethyl)chromen-2-ones as selective monoamine oxidase (MAO) A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.50 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 6.62 |
| CHEMBL3113645 | — | — | 1 | 5.84 |
| CHEMBL3112600 | — | — | 1 | 5.71 |
| CHEMBL3113647 | — | — | 1 | 5.67 |
| CHEMBL3113644 | — | — | 1 | 5.42 |
| CHEMBL3113643 | — | — | 1 | 5.37 |
| CHEMBL3113646 | — | — | 1 | 5.35 |
| CHEMBL3113640 | — | — | 1 | 5.20 |
| CHEMBL3113642 | — | — | 1 | 5.07 |
| CHEMBL3113639 | — | — | 1 | 4.77 |
| CHEMBL3113648 | — | — | 1 | - |
| CHEMBL3113641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3113645 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL3112600 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL3113647 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL3113644 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL3113643 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL3113646 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL3113640 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL3113642 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL3113639 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3113648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3113641 | — | IC50 | > | 100000.0 | nM | - |