Assay Detail
Binding
CHEMBL3118263
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Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional epoxide hydrolase 2 (CHEMBL5669) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.02 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3114595 | — | — | 1 | 8.49 |
| CHEMBL3114618 | — | — | 1 | 8.46 |
| CHEMBL3114609 | — | — | 1 | 8.39 |
| CHEMBL3114592 | — | — | 1 | 8.38 |
| CHEMBL3114600 | — | — | 1 | 8.30 |
| CHEMBL3114599 | — | — | 1 | 8.29 |
| CHEMBL3114617 | — | — | 1 | 8.28 |
| CHEMBL3114602 | — | — | 1 | 8.23 |
| CHEMBL3114593 | — | — | 1 | 8.19 |
| CHEMBL3114610 | — | — | 1 | 8.18 |
| CHEMBL3114608 | — | — | 1 | 8.18 |
| CHEMBL3114603 | — | — | 1 | 8.17 |
| CHEMBL3114594 | — | — | 1 | 8.17 |
| CHEMBL3114590 | — | — | 1 | 8.10 |
| CHEMBL1615216 | — | — | 1 | 8.08 |
| CHEMBL3114597 | — | — | 1 | 8.05 |
| CHEMBL3114591 | — | — | 1 | 8.03 |
| CHEMBL3114596 | — | — | 1 | 7.98 |
| CHEMBL3114614 | — | — | 1 | 7.91 |
| CHEMBL3114598 | — | — | 1 | 7.89 |
| CHEMBL3114611 | — | — | 1 | 7.74 |
| CHEMBL3114613 | — | — | 1 | 7.70 |
| CHEMBL3114601 | — | — | 1 | 7.68 |
| CHEMBL3114616 | — | — | 1 | 7.59 |
| CHEMBL3114606 | — | — | 1 | 7.49 |
| CHEMBL3114612 | — | — | 1 | 7.45 |
| CHEMBL3114607 | — | — | 1 | 7.25 |
| CHEMBL3114604 | — | — | 1 | - |
| CHEMBL3114605 | — | — | 1 | - |
| CHEMBL3114615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3114595 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3114618 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3114609 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3114592 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3114600 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3114599 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL3114617 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3114602 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3114593 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3114610 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3114608 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3114603 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3114594 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3114590 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1615216 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3114597 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3114591 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3114596 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL3114614 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3114598 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL3114611 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL3114613 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL3114601 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL3114616 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL3114606 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL3114612 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL3114607 | — | IC50 | = | 56.6 | nM | 7.25 |
| CHEMBL3114604 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3114605 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3114615 | — | IC50 | > | 100.0 | nM | - |