Assay Detail
Binding
CHEMBL3118265
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Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.92 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3114618 | — | — | 1 | 8.70 |
| CHEMBL3114595 | — | — | 1 | 8.68 |
| CHEMBL3114609 | — | — | 1 | 8.59 |
| CHEMBL3114592 | — | — | 1 | 8.51 |
| CHEMBL3114608 | — | — | 1 | 8.48 |
| CHEMBL3114610 | — | — | 1 | 8.37 |
| CHEMBL1615216 | — | — | 1 | 8.21 |
| CHEMBL3114599 | — | — | 1 | 8.13 |
| CHEMBL3114593 | — | — | 1 | 8.05 |
| CHEMBL3114600 | — | — | 1 | 7.99 |
| CHEMBL3114602 | — | — | 1 | 7.97 |
| CHEMBL3114598 | — | — | 1 | 7.95 |
| CHEMBL3114590 | — | — | 1 | 7.92 |
| CHEMBL3114603 | — | — | 1 | 7.92 |
| CHEMBL3114594 | — | — | 1 | 7.85 |
| CHEMBL3114601 | — | — | 1 | 7.83 |
| CHEMBL3114596 | — | — | 1 | 7.80 |
| CHEMBL3114611 | — | — | 1 | 7.75 |
| CHEMBL3114591 | — | — | 1 | 7.65 |
| CHEMBL3114614 | — | — | 1 | 7.61 |
| CHEMBL3114613 | — | — | 1 | 7.60 |
| CHEMBL3114617 | — | — | 1 | 7.57 |
| CHEMBL3114616 | — | — | 1 | 7.57 |
| CHEMBL3114612 | — | — | 1 | 7.56 |
| CHEMBL3114597 | — | — | 1 | 7.53 |
| CHEMBL3114606 | — | — | 1 | 7.52 |
| CHEMBL3114607 | — | — | 1 | 7.37 |
| CHEMBL3114615 | — | — | 1 | 7.03 |
| CHEMBL3114604 | — | — | 1 | - |
| CHEMBL3114605 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3114618 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3114595 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3114609 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3114592 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3114608 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3114610 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1615216 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3114599 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3114593 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3114600 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL3114602 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL3114598 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL3114590 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3114603 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3114594 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL3114601 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL3114596 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL3114611 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3114591 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL3114614 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL3114613 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL3114617 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL3114616 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL3114612 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL3114597 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL3114606 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL3114607 | — | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL3114615 | — | IC50 | = | 94.2 | nM | 7.03 |
| CHEMBL3114604 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3114605 | — | IC50 | > | 100.0 | nM | - |