Assay Detail
Binding
CHEMBL3118377
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Inhibition of human recombinant DPP4 (39 to 766)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.85 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3112968 | — | — | 1 | 8.70 |
| CHEMBL3112959 | — | — | 1 | 8.52 |
| CHEMBL3112960 | — | — | 1 | 8.40 |
| CHEMBL3112967 | — | — | 1 | 8.15 |
| CHEMBL3112971 | — | — | 1 | 8.05 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 8.00 |
| CHEMBL3112966 | — | — | 1 | 7.70 |
| CHEMBL3112958 | — | — | 1 | 7.40 |
| CHEMBL3112970 | — | — | 1 | 7.40 |
| CHEMBL3112957 | — | — | 1 | 6.70 |
| CHEMBL3112969 | — | — | 1 | 6.60 |
| CHEMBL3112964 | — | — | 1 | 5.38 |
| CHEMBL3112961 | — | — | 1 | 4.92 |
| CHEMBL3112965 | — | — | 1 | 4.80 |
| CHEMBL3112962 | — | — | 1 | 4.70 |
| CHEMBL3112963 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3112968 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3112959 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3112960 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3112967 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3112971 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3112966 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3112958 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3112970 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3112957 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3112969 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3112964 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3112961 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3112965 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3112962 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3112963 | — | IC50 | = | 60000.0 | nM | 4.22 |