Assay Detail
Binding
CHEMBL3118993
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Inhibition of JAK2 (unknown origin)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.06 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 9.15 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.97 |
| CHEMBL3114776 | — | — | 1 | 6.31 |
| CHEMBL3114786 | — | — | 1 | 5.91 |
| CHEMBL3114771 | — | — | 1 | 5.90 |
| CHEMBL3114783 | — | — | 1 | 5.90 |
| CHEMBL3114761 | — | — | 1 | 5.83 |
| CHEMBL3114775 | — | — | 1 | 5.79 |
| CHEMBL3114774 | — | — | 1 | 5.67 |
| CHEMBL366266 | — | — | 1 | 5.42 |
| CHEMBL3114772 | — | — | 1 | 5.01 |
| CHEMBL3114785 | — | — | 1 | 5.00 |
| CHEMBL3114781 | — | — | 1 | 4.96 |
| CHEMBL3114784 | — | — | 1 | - |
| CHEMBL3114765 | — | — | 1 | - |
| CHEMBL3114773 | — | — | 1 | - |
| CHEMBL3114762 | — | — | 1 | - |
| CHEMBL3114770 | — | — | 1 | - |
| CHEMBL3114769 | — | — | 1 | - |
| CHEMBL3114768 | — | — | 1 | - |
| CHEMBL3114767 | — | — | 1 | - |
| CHEMBL3114766 | — | — | 1 | - |
| CHEMBL1650951 | — | — | 1 | - |
| CHEMBL3114763 | — | — | 1 | - |
| CHEMBL3114782 | — | — | 1 | - |
| CHEMBL3114764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL3114776 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3114786 | — | IC50 | = | 1238.0 | nM | 5.91 |
| CHEMBL3114771 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL3114783 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL3114761 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL3114775 | — | IC50 | = | 1637.0 | nM | 5.79 |
| CHEMBL3114774 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL366266 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL3114772 | — | IC50 | = | 9687.0 | nM | 5.01 |
| CHEMBL3114785 | — | IC50 | = | 10080.0 | nM | 5.00 |
| CHEMBL3114781 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL3114784 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114773 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114762 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114770 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114767 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1650951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114763 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114782 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3114764 | — | IC50 | > | 10000.0 | nM | - |