Assay Detail
Binding
CHEMBL3119092
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Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.02 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58150 | — | — | 1 | 6.62 |
| CHEMBL3113470 | — | — | 1 | 6.25 |
| CHEMBL57818 | — | — | 1 | 6.19 |
| CHEMBL60908 | — | — | 1 | 6.00 |
| CHEMBL11417 | STREPTONIGRIN | 2.0 | 1 | 5.60 |
| CHEMBL1714002 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58150 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3113470 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL57818 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL60908 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL11417 | STREPTONIGRIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1714002 | — | IC50 | = | 3300.0 | nM | 5.48 |