Assay Detail
Binding
CHEMBL3119489
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Inhibition of VGLUT (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The development of benzo- and naphtho-fused quinoline-2,4-dicarboxylic acids as vesicular glutamate transporter (VGLUT) inhibitors reveals a possible role for neuroactive steroids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.98 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1640 | TRYPAN BLUE | 4.0 | 1 | 7.30 |
| CHEMBL311816 | BROMOCRYPTINE | — | 1 | 4.66 |
| CHEMBL34453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1640 | TRYPAN BLUE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL311816 | BROMOCRYPTINE | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL34453 | — | Ki | = | 700000.0 | nM | - |