Assay Detail
Binding
CHEMBL3119689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assay
16
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and assay of retro-α4β1 integrin-targeting motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.10 | 8.82 |
| IC50 | 6 | 6.82 | 8.32 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88478 | — | — | 3 | 8.82 |
| CHEMBL3115407 | — | — | 3 | 7.22 |
| CHEMBL3115406 | — | — | 3 | 6.75 |
| CHEMBL3115405 | — | — | 3 | 5.62 |
| CHEMBL3115404 | — | — | 2 | - |
| CHEMBL3115408 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88478 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL88478 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3115407 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3115407 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3115406 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3115406 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3115405 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3115405 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3115405 | — | Inhibition | - | % | - | |
| CHEMBL3115406 | — | Inhibition | - | % | - | |
| CHEMBL3115407 | — | Inhibition | - | % | - | |
| CHEMBL88478 | — | Inhibition | - | % | - | |
| CHEMBL3115404 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3115408 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3115404 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115408 | — | IC50 | > | 100000.0 | nM | - |