Assay Detail
Binding
CHEMBL3119794
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Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel coumarin-dihydropyrazole thio-ethanone derivatives: design, synthesis and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.65 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27323 | — | — | 1 | 6.55 |
| CHEMBL3115514 | — | — | 1 | 6.04 |
| CHEMBL3115522 | — | — | 1 | 5.98 |
| CHEMBL3115524 | — | — | 1 | 5.92 |
| CHEMBL3115509 | — | — | 1 | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.68 |
| CHEMBL3115523 | — | — | 1 | 5.33 |
| CHEMBL3115513 | — | — | 1 | 5.05 |
| CHEMBL3115516 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27323 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3115514 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3115522 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3115524 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3115509 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3115523 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL3115513 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL3115516 | — | IC50 | = | 25110.0 | nM | 4.60 |