Assay Detail
Binding
CHEMBL3119935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX-2 in human whole blood assessed as PGE2 level in plasma after 5 mins by enzyme immunoassay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.70 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3113234 | — | — | 1 | 7.05 |
| CHEMBL3113239 | — | — | 1 | 6.62 |
| CHEMBL3113224 | — | — | 1 | 6.58 |
| CHEMBL3113235 | — | — | 1 | 6.52 |
| CHEMBL3113240 | — | — | 1 | 6.52 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.46 |
| CHEMBL3113231 | — | — | 1 | 6.26 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | 6.16 |
| CHEMBL3113229 | — | — | 1 | 5.98 |
| CHEMBL3113236 | — | — | 1 | 5.80 |
| CHEMBL3113233 | — | — | 1 | 5.71 |
| CHEMBL3113237 | — | — | 1 | 5.64 |
| CHEMBL3113241 | — | — | 1 | 5.00 |
| CHEMBL3113242 | — | — | 1 | 4.68 |
| CHEMBL3113232 | — | — | 1 | 4.51 |
| CHEMBL3113228 | — | — | 1 | 4.46 |
| CHEMBL3113226 | — | — | 1 | 4.44 |
| CHEMBL3113227 | — | — | 1 | 4.25 |
| CHEMBL3113225 | — | — | 1 | - |
| CHEMBL3113230 | — | — | 1 | - |
| CHEMBL3113238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3113234 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3113239 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3113224 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3113235 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3113240 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL118 | CELECOXIB | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3113231 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3113229 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3113236 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3113233 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3113237 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL3113241 | — | IC50 | = | 10050.0 | nM | 5.00 |
| CHEMBL3113242 | — | IC50 | = | 20680.0 | nM | 4.68 |
| CHEMBL3113232 | — | IC50 | = | 30740.0 | nM | 4.51 |
| CHEMBL3113228 | — | IC50 | = | 35090.0 | nM | 4.46 |
| CHEMBL3113226 | — | IC50 | = | 36230.0 | nM | 4.44 |
| CHEMBL3113227 | — | IC50 | = | 56760.0 | nM | 4.25 |
| CHEMBL3113225 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3113230 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3113238 | — | IC50 | > | 100000.0 | nM | - |