Assay Detail
Functional
CHEMBL3122352
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Antiplasmodial activity against chloroquine-resistant blood stage Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I-based fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.87 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.31 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 5.39 |
| CHEMBL337309 | TAXIFOLIN | — | 1 | 4.26 |
| CHEMBL3121245 | — | — | 1 | 4.18 |
| CHEMBL3121246 | — | — | 1 | 4.06 |
| CHEMBL402471 | ISOCRENATOSIDE | — | 1 | 4.03 |
| CHEMBL3121248 | — | — | 1 | - |
| CHEMBL2048508 | — | — | 1 | - |
| CHEMBL3121247 | — | — | 1 | - |
| CHEMBL2048505 | DIMETHYL LITHOSPERMATE | — | 1 | - |
| CHEMBL2048506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL250450 | ISOQUERCETIN | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL337309 | TAXIFOLIN | IC50 | = | 54960.0 | nM | 4.26 |
| CHEMBL3121245 | — | IC50 | = | 66680.0 | nM | 4.18 |
| CHEMBL3121246 | — | IC50 | = | 86750.0 | nM | 4.06 |
| CHEMBL402471 | ISOCRENATOSIDE | IC50 | = | 93110.0 | nM | 4.03 |
| CHEMBL3121248 | — | IC50 | - | — | - | |
| CHEMBL2048508 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3121247 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2048505 | DIMETHYL LITHOSPERMATE | IC50 | - | — | - | |
| CHEMBL2048506 | — | IC50 | - | — | - |