Assay Detail
Functional
CHEMBL3122821
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Antiviral activity against Hepatitis C virus genotype 2a expressed in human Huh-7 Lunet cells cells after 48 hrs by luciferase reporter gene assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.63 | 7.90 |
| EC50 | 1 | 7.70 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121308 | — | — | 3 | 7.90 |
| CHEMBL3121328 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121308 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3121308 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3121328 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3121308 | — | IC50 | = | 79.43 | nM | 7.10 |