Assay Detail
Functional
CHEMBL3122822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus genotype 1b expressed in ET cells after 48 hrs by luciferase reporter gene assay
28
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | ET |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.19 | 9.40 |
| EC50 | 1 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121319 | — | — | 1 | 9.40 |
| CHEMBL3121334 | — | — | 1 | 9.30 |
| CHEMBL3121318 | — | — | 1 | 9.30 |
| CHEMBL3121322 | — | — | 1 | 9.20 |
| CHEMBL3121323 | — | — | 1 | 9.00 |
| CHEMBL3121320 | — | — | 1 | 8.90 |
| CHEMBL3121308 | — | — | 3 | 8.60 |
| CHEMBL3121311 | — | — | 1 | 8.60 |
| CHEMBL3121321 | — | — | 1 | 8.50 |
| CHEMBL3121328 | — | — | 1 | 8.40 |
| CHEMBL3121326 | — | — | 1 | 8.40 |
| CHEMBL3121324 | — | — | 1 | 8.30 |
| CHEMBL3121312 | — | — | 1 | 8.20 |
| CHEMBL3121310 | — | — | 1 | 8.00 |
| CHEMBL3121329 | — | — | 1 | 8.00 |
| CHEMBL3121314 | — | — | 1 | 7.80 |
| CHEMBL3121333 | — | — | 1 | 7.80 |
| CHEMBL3121325 | — | — | 1 | 7.70 |
| CHEMBL3121316 | — | — | 1 | 7.70 |
| CHEMBL3121317 | — | — | 1 | 7.50 |
| CHEMBL3121313 | — | — | 1 | 7.50 |
| CHEMBL3121309 | — | — | 1 | 7.10 |
| CHEMBL3121330 | — | — | 1 | 6.90 |
| CHEMBL3121331 | — | — | 1 | 6.80 |
| CHEMBL3121315 | — | — | 1 | - |
| CHEMBL3121332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121319 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL3121334 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL3121318 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL3121322 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL3121323 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3121320 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL3121308 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3121311 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3121308 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3121321 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3121328 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3121326 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3121324 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3121312 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3121329 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3121310 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3121333 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3121308 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3121314 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3121316 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3121325 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3121313 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3121317 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3121309 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3121330 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3121331 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3121315 | — | IC50 | > | 1995.26 | nM | - |
| CHEMBL3121332 | — | IC50 | > | 5011.87 | nM | - |