Assay Detail
Binding
CHEMBL3122824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (2 to 1102) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured after 45 to 60 mins
29
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.50 | 8.60 |
| pIC50 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121327 | — | — | 1 | 8.60 |
| CHEMBL3121334 | — | — | 1 | 8.40 |
| CHEMBL3121323 | — | — | 1 | 8.20 |
| CHEMBL3121333 | — | — | 1 | 8.10 |
| CHEMBL3121319 | — | — | 1 | 7.40 |
| CHEMBL3121322 | — | — | 1 | 7.30 |
| CHEMBL3121320 | — | — | 1 | 7.30 |
| CHEMBL3121329 | — | — | 1 | 7.20 |
| CHEMBL3121325 | — | — | 1 | 6.80 |
| CHEMBL3121311 | — | — | 1 | 6.50 |
| CHEMBL3121313 | — | — | 1 | 6.50 |
| CHEMBL3121310 | — | — | 1 | 6.40 |
| CHEMBL3121317 | — | — | 1 | 6.30 |
| CHEMBL3121326 | — | — | 1 | 6.30 |
| CHEMBL3121328 | — | — | 1 | 6.20 |
| CHEMBL3121316 | — | — | 1 | 6.10 |
| CHEMBL3121312 | — | — | 1 | 6.00 |
| CHEMBL3121331 | — | — | 1 | 5.90 |
| CHEMBL3121324 | — | — | 1 | 5.90 |
| CHEMBL3121309 | — | — | 1 | 5.80 |
| CHEMBL3121308 | — | — | 3 | 5.60 |
| CHEMBL3121315 | — | — | 1 | 5.40 |
| CHEMBL3121330 | — | — | 1 | 5.20 |
| CHEMBL3121332 | — | — | 1 | 4.60 |
| CHEMBL3121314 | — | — | 1 | - |
| CHEMBL3121318 | — | — | 1 | - |
| CHEMBL3121321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121327 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3121334 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3121323 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3121333 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3121319 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3121322 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3121320 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3121329 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3121325 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3121311 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3121313 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3121310 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3121326 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3121317 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3121328 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3121316 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3121312 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3121324 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3121331 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3121309 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3121308 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL3121308 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL3121308 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL3121315 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3121330 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL3121332 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL3121314 | — | pIC50 | - | — | - | |
| CHEMBL3121318 | — | pIC50 | - | — | - | |
| CHEMBL3121321 | — | pIC50 | - | — | - |