Assay Detail
Binding
CHEMBL3122826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (1 to 1070)/6xHis-tagged p85 (1 to 724) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured after 45 to 60 mins
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121327 | — | — | 1 | 8.70 |
| CHEMBL3121334 | — | — | 1 | 7.00 |
| CHEMBL3121323 | — | — | 1 | 7.00 |
| CHEMBL3121333 | — | — | 1 | 6.70 |
| CHEMBL3121319 | — | — | 1 | 6.40 |
| CHEMBL3121325 | — | — | 1 | 6.40 |
| CHEMBL3121318 | — | — | 1 | 6.30 |
| CHEMBL3121320 | — | — | 1 | 6.30 |
| CHEMBL3121322 | — | — | 1 | 6.30 |
| CHEMBL3121330 | — | — | 1 | 6.00 |
| CHEMBL3121329 | — | — | 1 | 5.90 |
| CHEMBL3121331 | — | — | 1 | 5.80 |
| CHEMBL3121311 | — | — | 1 | 5.70 |
| CHEMBL3121321 | — | — | 1 | 5.60 |
| CHEMBL3121326 | — | — | 1 | 5.40 |
| CHEMBL3121317 | — | — | 1 | 5.30 |
| CHEMBL3121316 | — | — | 1 | 5.30 |
| CHEMBL3121314 | — | — | 1 | 5.30 |
| CHEMBL3121308 | — | — | 3 | 5.10 |
| CHEMBL3121309 | — | — | 1 | 5.00 |
| CHEMBL3121328 | — | — | 1 | 5.00 |
| CHEMBL3121324 | — | — | 1 | 4.90 |
| CHEMBL3121312 | — | — | 1 | 4.80 |
| CHEMBL3121310 | — | — | 1 | 4.60 |
| CHEMBL3121315 | — | — | 1 | 4.50 |
| CHEMBL3121332 | — | — | 1 | 4.20 |
| CHEMBL3121313 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121327 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3121334 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3121323 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3121333 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3121319 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3121325 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3121322 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3121320 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3121318 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3121330 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3121329 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL3121331 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3121311 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3121321 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL3121326 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3121316 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL3121314 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL3121317 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL3121308 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3121308 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3121309 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3121328 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3121324 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3121308 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL3121312 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL3121310 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL3121315 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL3121332 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3121313 | — | IC50 | = | 100000.0 | nM | 4.00 |