Assay Detail
Binding
CHEMBL3122829
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Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by substrate addition measured after 180 mins by luminescence assay
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.69 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121323 | — | — | 1 | 9.50 |
| CHEMBL3121314 | — | — | 1 | 9.10 |
| CHEMBL3121319 | — | — | 1 | 9.00 |
| CHEMBL3121322 | — | — | 1 | 9.00 |
| CHEMBL3121327 | — | — | 1 | 8.80 |
| CHEMBL3121334 | — | — | 1 | 8.80 |
| CHEMBL3121318 | — | — | 1 | 8.60 |
| CHEMBL3121320 | — | — | 1 | 8.40 |
| CHEMBL3121308 | — | — | 3 | 8.30 |
| CHEMBL3121333 | — | — | 1 | 8.30 |
| CHEMBL3121324 | — | — | 1 | 8.20 |
| CHEMBL3121326 | — | — | 1 | 8.00 |
| CHEMBL3121311 | — | — | 1 | 8.00 |
| CHEMBL3121321 | — | — | 1 | 7.80 |
| CHEMBL3121316 | — | — | 1 | 7.70 |
| CHEMBL3121312 | — | — | 1 | 7.50 |
| CHEMBL3121325 | — | — | 1 | 7.40 |
| CHEMBL3121328 | — | — | 1 | 7.40 |
| CHEMBL3121310 | — | — | 1 | 7.30 |
| CHEMBL3121309 | — | — | 1 | 7.30 |
| CHEMBL3121329 | — | — | 1 | 7.00 |
| CHEMBL3121317 | — | — | 1 | 6.90 |
| CHEMBL3121331 | — | — | 1 | 6.70 |
| CHEMBL3121313 | — | — | 1 | 6.50 |
| CHEMBL3121330 | — | — | 1 | 6.20 |
| CHEMBL3121315 | — | — | 1 | 5.40 |
| CHEMBL3121332 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121323 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL3121314 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL3121319 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3121322 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3121327 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL3121334 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL3121318 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3121320 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3121333 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3121308 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3121324 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3121326 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3121311 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3121321 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3121308 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3121316 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3121312 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3121325 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3121328 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3121310 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3121309 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3121329 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3121317 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3121308 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3121331 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL3121313 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3121330 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3121315 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3121332 | — | IC50 | = | 7943.28 | nM | 5.10 |