Assay Detail
Binding
CHEMBL3123092
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Inhibition of Hepatitis C virus genotype 1a full-length NS3/NS4A protease assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.51 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 8.80 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 8.68 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.77 |
| CHEMBL2369589 | — | — | 1 | 4.77 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL297884 | CILUPREVIR | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL231813 | TELAPREVIR | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL2369589 | — | Kd | = | 17000.0 | nM | 4.77 |
| CHEMBL218394 | BOCEPREVIR | Kd | - | — | - |