Assay Detail
Functional
CHEMBL3123472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus genotype 1b harboring NS5A Y93H mutant gene in Huh-luc/neo-ET replicon cells after 48 hrs by transient replicon mutant-based luciferase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-luc/neo-ET |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.98 | 10.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3121953 | — | — | 1 | 10.90 |
| CHEMBL3121951 | — | — | 1 | 10.60 |
| CHEMBL3121952 | — | — | 1 | 9.90 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 9.50 |
| CHEMBL3122036 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3121953 | — | EC50 | = | 0.01259 | nM | 10.90 |
| CHEMBL3121951 | — | EC50 | = | 0.02512 | nM | 10.60 |
| CHEMBL3121952 | — | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL3122036 | — | EC50 | = | 1.0 | nM | 9.00 |