Assay Detail
Binding
CHEMBL3124063
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Inhibition of Hepatitis C virus genotype 3a NS3/4A protease assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 3a |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.86 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348818 | — | — | 1 | 10.10 |
| CHEMBL3349199 | — | — | 1 | 9.96 |
| CHEMBL3120475 | — | — | 1 | 9.92 |
| CHEMBL3348817 | — | — | 1 | 9.85 |
| CHEMBL3349202 | — | — | 1 | 9.55 |
| CHEMBL3120477 | — | — | 1 | 9.52 |
| CHEMBL3349203 | — | — | 1 | 9.39 |
| CHEMBL3120476 | — | — | 1 | 9.39 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 9.15 |
| CHEMBL3120493 | — | — | 1 | 9.15 |
| CHEMBL3120492 | — | — | 1 | 8.94 |
| CHEMBL3349201 | — | — | 1 | 8.92 |
| CHEMBL3120488 | — | — | 1 | 8.92 |
| CHEMBL3120479 | — | — | 1 | 8.91 |
| CHEMBL3120478 | — | — | 1 | 8.88 |
| CHEMBL3120491 | — | — | 1 | 8.72 |
| CHEMBL3120169 | — | — | 1 | 8.70 |
| CHEMBL3120482 | — | — | 1 | 8.67 |
| CHEMBL3120489 | — | — | 1 | 8.35 |
| CHEMBL3349200 | — | — | 1 | 8.33 |
| CHEMBL3120480 | — | — | 1 | 8.29 |
| CHEMBL3120490 | — | — | 1 | 8.12 |
| CHEMBL3120483 | — | — | 1 | 7.96 |
| CHEMBL3120481 | — | — | 1 | 6.98 |
| CHEMBL3120474 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348818 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3349199 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL3120475 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL3348817 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3349202 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL3120477 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3349203 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL3120476 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3120493 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL3120492 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL3349201 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3120488 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3120479 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL3120478 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL3120491 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3120169 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3120482 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL3120489 | — | IC50 | = | 4.45 | nM | 8.35 |
| CHEMBL3349200 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3120480 | — | IC50 | = | 5.18 | nM | 8.29 |
| CHEMBL3120490 | — | IC50 | = | 7.55 | nM | 8.12 |
| CHEMBL3120483 | — | IC50 | = | 10.98 | nM | 7.96 |
| CHEMBL3120481 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3120474 | — | IC50 | = | 191.2 | nM | 6.72 |