Assay Detail
Binding
CHEMBL3124064
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Inhibition of Hepatitis C virus genotype 1b NS3/4A protease assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 10.65 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120169 | — | — | 1 | 11.00 |
| CHEMBL3348817 | — | — | 1 | 11.00 |
| CHEMBL3120491 | — | — | 1 | 11.00 |
| CHEMBL3120482 | — | — | 1 | 11.00 |
| CHEMBL3120492 | — | — | 1 | 11.00 |
| CHEMBL3120475 | — | — | 1 | 11.00 |
| CHEMBL3349199 | — | — | 1 | 11.00 |
| CHEMBL3120477 | — | — | 1 | 11.00 |
| CHEMBL3348818 | — | — | 1 | 11.00 |
| CHEMBL3120489 | — | — | 1 | 10.70 |
| CHEMBL3349202 | — | — | 1 | 10.70 |
| CHEMBL3349201 | — | — | 1 | 10.70 |
| CHEMBL3349200 | — | — | 1 | 10.70 |
| CHEMBL3120480 | — | — | 1 | 10.70 |
| CHEMBL3120493 | — | — | 1 | 10.70 |
| CHEMBL3120488 | — | — | 1 | 10.70 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 10.70 |
| CHEMBL3120478 | — | — | 1 | 10.70 |
| CHEMBL3120476 | — | — | 1 | 10.52 |
| CHEMBL3120483 | — | — | 1 | 10.52 |
| CHEMBL3120490 | — | — | 1 | 10.52 |
| CHEMBL3349203 | — | — | 1 | 10.40 |
| CHEMBL3120479 | — | — | 1 | 9.82 |
| CHEMBL3120474 | — | — | 1 | 9.80 |
| CHEMBL3120481 | — | — | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120169 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3348817 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3120491 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3120482 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3120492 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3120475 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3349199 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3120477 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3348818 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3120489 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3349202 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3349201 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3349200 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3120480 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3120493 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3120488 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3120478 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3120476 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3120483 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3120490 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3349203 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3120479 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3120474 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL3120481 | — | IC50 | = | 0.4 | nM | 9.40 |