Assay Detail
Functional
CHEMBL3124089
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Antiviral activity against Hepatitis C virus genotype 1b isolate Con1 harboring wild type NS2-NS5B gene assessed as luciferase activity after 72 hrs by cell-based replicon assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 9.36 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120774 | — | — | 1 | 9.89 |
| CHEMBL3120773 | — | — | 1 | 9.77 |
| CHEMBL3120772 | — | — | 1 | 9.52 |
| CHEMBL3120770 | — | — | 1 | 9.40 |
| CHEMBL3120769 | — | — | 1 | 9.40 |
| CHEMBL3120775 | — | — | 1 | 9.22 |
| CHEMBL3120771 | — | — | 1 | 9.15 |
| CHEMBL1241348 | FALDAPREVIR | 3.0 | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120774 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3120773 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3120772 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3120770 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3120769 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3120775 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3120771 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1241348 | FALDAPREVIR | EC50 | = | 3.1 | nM | 8.51 |