Assay Detail
Functional
CHEMBL3124118
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Antiviral activity against Influenza A virus H3N2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.20 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.62 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 9.35 |
| CHEMBL81717 | — | — | 1 | 9.10 |
| CHEMBL3120197 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL81717 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3120197 | — | IC50 | = | 1.82 | nM | 8.74 |