Assay Detail
Binding
CHEMBL3124119
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Inhibition of neuraminidase in Influenza A virus A/Rheinland-Pfalz/3911/03(H3N2) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.36 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 9.77 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 9.70 |
| CHEMBL81717 | — | — | 1 | 9.20 |
| CHEMBL3120197 | — | — | 1 | 8.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL81717 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL3120197 | — | IC50 | = | 1.79 | nM | 8.75 |