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Assay Detail

CHEMBL3124245

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis B virus
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis B virus (CHEMBL613497)
Type ORGANISM
Organism Hepatitis B virus

Publication

A review of non-nucleoside anti-hepatitis B virus agents.
Zhang F, Wang G.
Eur J Med Chem (2014) 75 : 267 -281
PubMed 24549242 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 6.81 7.52
IC50 8 4.35 4.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL369673 1 7.52
CHEMBL367646 1 7.10
CHEMBL1241274 1 6.92
CHEMBL1241273 1 6.92
CHEMBL1241394 1 6.92
CHEMBL1401 NITAZOXANIDE 4.0 1 6.92
CHEMBL1241302 1 6.92
CHEMBL175499 1 6.10
CHEMBL436474 HELIOXANTHIN 1 6.00
CHEMBL3121571 1 4.46
CHEMBL3121573 1 4.40
CHEMBL3121572 1 4.20
CHEMBL3121576 1 -
CHEMBL3121577 1 -
CHEMBL3120179 1 -
CHEMBL3121578 1 -
CHEMBL3121579 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL369673 EC50 = 30.0 nM 7.52
CHEMBL367646 EC50 = 80.0 nM 7.10
CHEMBL1241274 EC50 = 120.0 nM 6.92
CHEMBL1241273 EC50 = 120.0 nM 6.92
CHEMBL1241394 EC50 = 120.0 nM 6.92
CHEMBL1401 NITAZOXANIDE EC50 = 120.0 nM 6.92
CHEMBL1241302 EC50 = 120.0 nM 6.92
CHEMBL175499 EC50 = 800.0 nM 6.10
CHEMBL436474 HELIOXANTHIN EC50 = 1000.0 nM 6.00
CHEMBL3121571 IC50 = 35000.0 nM 4.46
CHEMBL3121573 IC50 = 40000.0 nM 4.40
CHEMBL3121572 IC50 = 63000.0 nM 4.20
CHEMBL3121576 IC50 < 60.0 ug.mL-1 -
CHEMBL3121577 IC50 < 60.0 ug.mL-1 -
CHEMBL3120179 IC50 < 60.0 ug.mL-1 -
CHEMBL3121578 IC50 < 60.0 ug.mL-1 -
CHEMBL3121579 IC50 < 60.0 ug.mL-1 -