Assay Detail
Binding
CHEMBL3124634
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Binding affinity to STAT1 (unknown origin) by surface plasmon resonance assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 1-alpha/beta (CHEMBL6101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.24 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.16 |
| CHEMBL3120621 | — | — | 1 | 5.33 |
| CHEMBL502489 | GARCINOL | — | 1 | 4.77 |
| CHEMBL388529 | GUTTIFERONE K | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL3120621 | — | Kd | = | 4670.0 | nM | 5.33 |
| CHEMBL502489 | GARCINOL | Kd | = | 16900.0 | nM | 4.77 |
| CHEMBL388529 | GUTTIFERONE K | Kd | = | 20600.0 | nM | 4.69 |