Assay Detail
Functional
CHEMBL3124681
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Antiviral activity against Oseltamivir-resistant Influenza A virus A/Berlin/55/08(H1N1) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.57 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 5.91 |
| CHEMBL81717 | — | — | 1 | 5.48 |
| CHEMBL3120197 | — | — | 1 | 5.32 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL81717 | — | EC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL3120197 | — | EC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | > | 100000.0 | nM | - |