Assay Detail
Binding
CHEMBL3128336
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Displacement of [3H]nisoxetine from Sprague-Dawley rat brain NET after 180 mins by liquid scintillation counting analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 4.92 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1516187 | — | — | 1 | 6.01 |
| CHEMBL3126736 | — | — | 1 | 5.50 |
| CHEMBL3126717 | — | — | 1 | 5.49 |
| CHEMBL3126735 | — | — | 1 | 5.42 |
| CHEMBL3126734 | — | — | 1 | 5.26 |
| CHEMBL3126718 | — | — | 1 | 5.25 |
| CHEMBL3126730 | — | — | 1 | 5.16 |
| CHEMBL3126756 | — | — | 1 | 5.12 |
| CHEMBL3126744 | — | — | 1 | 5.12 |
| CHEMBL3126721 | — | — | 1 | 5.10 |
| CHEMBL3126731 | — | — | 1 | 5.07 |
| CHEMBL3126719 | — | — | 1 | 5.06 |
| CHEMBL3126751 | — | — | 1 | 5.01 |
| CHEMBL3126738 | — | — | 1 | 4.97 |
| CHEMBL3126752 | — | — | 1 | 4.96 |
| CHEMBL3126733 | — | — | 1 | 4.94 |
| CHEMBL3126732 | — | — | 1 | 4.76 |
| CHEMBL3126737 | — | — | 1 | 4.61 |
| CHEMBL3126750 | — | — | 1 | 4.57 |
| CHEMBL3126720 | — | — | 1 | 4.45 |
| CHEMBL3126749 | — | — | 1 | 4.34 |
| CHEMBL3126743 | — | — | 1 | 4.25 |
| CHEMBL3126740 | — | — | 1 | 4.24 |
| CHEMBL3126755 | — | — | 1 | 4.22 |
| CHEMBL3126754 | — | — | 1 | 4.17 |
| CHEMBL3126716 | — | — | 1 | - |
| CHEMBL3126753 | — | — | 1 | - |
| CHEMBL3126724 | — | — | 1 | - |
| CHEMBL3126748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1516187 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL3126736 | — | Ki | = | 3160.0 | nM | 5.50 |
| CHEMBL3126717 | — | Ki | = | 3270.0 | nM | 5.49 |
| CHEMBL3126735 | — | Ki | = | 3850.0 | nM | 5.42 |
| CHEMBL3126734 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL3126718 | — | Ki | = | 5670.0 | nM | 5.25 |
| CHEMBL3126730 | — | Ki | = | 6920.0 | nM | 5.16 |
| CHEMBL3126756 | — | Ki | = | 7540.0 | nM | 5.12 |
| CHEMBL3126744 | — | Ki | = | 7580.0 | nM | 5.12 |
| CHEMBL3126721 | — | Ki | = | 7960.0 | nM | 5.10 |
| CHEMBL3126731 | — | Ki | = | 8540.0 | nM | 5.07 |
| CHEMBL3126719 | — | Ki | = | 8650.0 | nM | 5.06 |
| CHEMBL3126751 | — | Ki | = | 9770.0 | nM | 5.01 |
| CHEMBL3126738 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL3126752 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL3126733 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL3126732 | — | Ki | = | 17300.0 | nM | 4.76 |
| CHEMBL3126737 | — | Ki | = | 24500.0 | nM | 4.61 |
| CHEMBL3126750 | — | Ki | = | 27200.0 | nM | 4.57 |
| CHEMBL3126720 | — | Ki | = | 35500.0 | nM | 4.45 |
| CHEMBL3126749 | — | Ki | = | 45400.0 | nM | 4.34 |
| CHEMBL3126743 | — | Ki | = | 56100.0 | nM | 4.25 |
| CHEMBL3126740 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL3126755 | — | Ki | = | 59700.0 | nM | 4.22 |
| CHEMBL3126754 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL3126716 | — | Ki | = | 138000.0 | nM | - |
| CHEMBL3126753 | — | Ki | = | 171000.0 | nM | - |
| CHEMBL3126724 | — | Ki | - | — | - | |
| CHEMBL3126748 | — | Ki | = | 285000.0 | nM | - |