Assay Detail
Binding
CHEMBL3128341
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Binding affinity to wild type human DAT expressed in African green monkey COS7 cells assessed as inhibition of [3H]-dopamine uptake after 5 mins by beta-scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.58 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1516187 | — | — | 1 | 6.41 |
| CHEMBL3126730 | — | — | 1 | 5.92 |
| CHEMBL3126751 | — | — | 1 | 5.43 |
| CHEMBL3126750 | — | — | 1 | 5.26 |
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1516187 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3126730 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL3126751 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL3126750 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL1373 | MODAFINIL | Ki | = | 13000.0 | nM | 4.89 |