Assay Detail
Binding
CHEMBL3128639
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Inhibition of human SGLT2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel l-rhamnose derived acyclic C-nucleosides with substituted 1,2,3-triazole core as potent sodium-glucose co-transporter (SGLT) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.06 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125150 | — | — | 1 | 9.17 |
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 8.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125150 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 1.16 | nM | 8.94 |