Assay Detail
Functional
CHEMBL3128759
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Cytotoxicity against human A549 cells after 5 days by trypan blue exclusion assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.57 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128003 | — | — | 1 | 7.29 |
| CHEMBL3127995 | — | — | 1 | 7.00 |
| CHEMBL3127996 | — | — | 1 | 6.96 |
| CHEMBL3128002 | — | — | 1 | 6.80 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128003 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3127995 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3127996 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3128002 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL140 | CURCUMIN | IC50 | = | 15000.0 | nM | 4.82 |