Assay Detail
Binding
CHEMBL3128989
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Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.29 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128270 | — | — | 1 | 6.16 |
| CHEMBL3128273 | — | — | 1 | 6.00 |
| CHEMBL3128275 | — | — | 1 | 5.70 |
| CHEMBL112953 | — | — | 1 | 5.70 |
| CHEMBL3128287 | — | — | 1 | 5.60 |
| CHEMBL3128272 | — | — | 1 | 5.60 |
| CHEMBL3128285 | — | — | 1 | 5.40 |
| CHEMBL3128282 | — | — | 1 | 5.30 |
| CHEMBL3128276 | — | — | 1 | 5.12 |
| CHEMBL3128284 | — | — | 1 | 4.82 |
| CHEMBL3128279 | — | — | 1 | 4.70 |
| CHEMBL3128291 | — | — | 1 | 4.52 |
| CHEMBL3128288 | — | — | 1 | 4.12 |
| CHEMBL164 | MYRICETIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128270 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3128273 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3128275 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL112953 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3128287 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3128272 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3128285 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3128282 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3128276 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3128284 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3128279 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3128291 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3128288 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL164 | MYRICETIN | IC50 | > | 100000.0 | nM | - |