Assay Detail
Functional
CHEMBL3129122
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Cytotoxicity against human PC3 cells after 48 hrs by trypan blue exclusion assay
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| IC50 | 3 | 4.97 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336409 | — | — | 1 | 5.19 |
| CHEMBL3126646 | — | — | 1 | 5.18 |
| CHEMBL2385821 | — | — | 1 | 4.53 |
| CHEMBL3126652 | — | — | 1 | - |
| CHEMBL3126651 | — | — | 1 | - |
| CHEMBL3126645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336409 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3126646 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2385821 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL3126652 | — | Activity | - | — | - | |
| CHEMBL3126651 | — | Activity | - | — | - | |
| CHEMBL3126645 | — | Activity | - | — | - |