Assay Detail
Functional
CHEMBL3129231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells after 72 hrs by XTT assay
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 80 | 5.75 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 7.22 |
| CHEMBL3127049 | — | — | 1 | 6.66 |
| CHEMBL3127066 | — | — | 1 | 6.54 |
| CHEMBL3126914 | — | — | 1 | 6.54 |
| CHEMBL3127065 | — | — | 1 | 6.52 |
| CHEMBL3126908 | — | — | 1 | 6.52 |
| CHEMBL3127068 | — | — | 1 | 6.37 |
| CHEMBL3127058 | — | — | 1 | 6.07 |
| CHEMBL3126905 | — | — | 1 | 5.88 |
| CHEMBL3126906 | — | — | 1 | 5.74 |
| CHEMBL3126915 | — | — | 1 | 5.46 |
| CHEMBL3126911 | — | — | 1 | 5.33 |
| CHEMBL3126909 | — | — | 1 | 5.27 |
| CHEMBL3127044 | — | — | 1 | 5.26 |
| CHEMBL3126865 | — | — | 1 | 5.20 |
| CHEMBL3126880 | — | — | 1 | 4.92 |
| CHEMBL3126900 | — | — | 1 | 4.90 |
| CHEMBL3127047 | — | — | 1 | 4.90 |
| CHEMBL3127067 | — | — | 1 | 4.86 |
| CHEMBL3126907 | — | — | 1 | 4.86 |
| CHEMBL3126913 | — | — | 1 | - |
| CHEMBL3127050 | — | — | 1 | - |
| CHEMBL3126912 | — | — | 1 | - |
| CHEMBL3126904 | — | — | 1 | - |
| CHEMBL3126903 | — | — | 1 | - |
| CHEMBL3126902 | — | — | 1 | - |
| CHEMBL3126901 | — | — | 1 | - |
| CHEMBL319177 | — | — | 1 | - |
| CHEMBL3126898 | — | — | 1 | - |
| CHEMBL3127063 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3127049 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3127066 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3126914 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3127065 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3126908 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3127068 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3127058 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3126905 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3126906 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL3126915 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL3126911 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL3126909 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL3127044 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL3126865 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL3126880 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3127047 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3126900 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3127067 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3126907 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3127056 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127052 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3127054 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127051 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127048 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL403715 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127046 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127045 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126881 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3126879 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3126899 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3127064 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3127055 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3127057 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127059 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127060 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126898 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL319177 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126902 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127050 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3126913 | — | IC50 | > | 20000.0 | nM | - |