Assay Detail
ADMET
CHEMBL3129232
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Cytostatic activity against human MRC5 cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 4.51 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 7.05 |
| CHEMBL3126908 | — | — | 1 | 6.21 |
| CHEMBL3126914 | — | — | 1 | 5.84 |
| CHEMBL3127065 | — | — | 1 | 5.77 |
| CHEMBL3126915 | — | — | 1 | 4.88 |
| CHEMBL3126871 | — | — | 1 | 4.64 |
| CHEMBL3127044 | — | — | 1 | 4.61 |
| CHEMBL3127066 | — | — | 1 | 4.53 |
| CHEMBL3126905 | — | — | 1 | 4.44 |
| CHEMBL1814767 | — | — | 1 | 4.44 |
| CHEMBL1814768 | — | — | 1 | 4.41 |
| CHEMBL3127067 | — | — | 1 | 4.37 |
| CHEMBL3126906 | — | — | 1 | 4.24 |
| CHEMBL3127048 | — | — | 1 | 4.20 |
| CHEMBL3127046 | — | — | 1 | 4.18 |
| CHEMBL3127054 | — | — | 1 | 4.15 |
| CHEMBL3127049 | — | — | 1 | 4.13 |
| CHEMBL3127068 | — | — | 1 | 4.12 |
| CHEMBL3127063 | — | — | 1 | 4.12 |
| CHEMBL3126889 | — | — | 1 | 4.11 |
| CHEMBL3126913 | — | — | 1 | 4.07 |
| CHEMBL3126865 | — | — | 1 | 4.07 |
| CHEMBL3126874 | — | — | 1 | 4.07 |
| CHEMBL3126866 | — | — | 1 | 4.05 |
| CHEMBL3127058 | — | — | 1 | 4.04 |
| CHEMBL3126907 | — | — | 1 | 4.04 |
| CHEMBL3126895 | — | — | 1 | 4.04 |
| CHEMBL3126898 | — | — | 1 | 4.01 |
| CHEMBL3126909 | — | — | 1 | 4.01 |
| CHEMBL3127062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3126908 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3126914 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3127065 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3126915 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3126871 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL3127044 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL3127066 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL3126905 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL1814767 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL1814768 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL3127067 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL3126906 | — | IC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL3127048 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL3127046 | — | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL3127054 | — | IC50 | = | 70800.0 | nM | 4.15 |
| CHEMBL3127049 | — | IC50 | = | 73900.0 | nM | 4.13 |
| CHEMBL3127068 | — | IC50 | = | 75300.0 | nM | 4.12 |
| CHEMBL3127063 | — | IC50 | = | 75300.0 | nM | 4.12 |
| CHEMBL3126889 | — | IC50 | = | 78500.0 | nM | 4.11 |
| CHEMBL3126913 | — | IC50 | = | 84400.0 | nM | 4.07 |
| CHEMBL3126865 | — | IC50 | = | 85800.0 | nM | 4.07 |
| CHEMBL3126874 | — | IC50 | = | 86100.0 | nM | 4.07 |
| CHEMBL3126866 | — | IC50 | = | 89700.0 | nM | 4.05 |
| CHEMBL3126895 | — | IC50 | = | 91800.0 | nM | 4.04 |
| CHEMBL3126907 | — | IC50 | = | 91700.0 | nM | 4.04 |
| CHEMBL3127058 | — | IC50 | = | 90800.0 | nM | 4.04 |
| CHEMBL3126898 | — | IC50 | = | 97800.0 | nM | 4.01 |
| CHEMBL3126909 | — | IC50 | = | 98300.0 | nM | 4.01 |
| CHEMBL3127053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127056 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127057 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127060 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127061 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127045 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127064 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319177 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126902 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3126879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 100000.0 | nM | - |