Assay Detail
Functional
CHEMBL3129237
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Cytostatic activity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 5.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814768 | — | — | 1 | 7.70 |
| CHEMBL1814767 | — | — | 1 | 7.30 |
| CHEMBL3126907 | — | — | 1 | 7.30 |
| CHEMBL1269812 | — | — | 1 | 7.30 |
| CHEMBL3127055 | — | — | 1 | 7.16 |
| CHEMBL3127056 | — | — | 1 | 7.00 |
| CHEMBL3126908 | — | — | 1 | 6.96 |
| CHEMBL3126914 | — | — | 1 | 6.96 |
| CHEMBL3127049 | — | — | 1 | 6.68 |
| CHEMBL3126905 | — | — | 1 | 6.58 |
| CHEMBL3127065 | — | — | 1 | 6.42 |
| CHEMBL3127047 | — | — | 1 | 6.42 |
| CHEMBL3126906 | — | — | 1 | 6.05 |
| CHEMBL3126898 | — | — | 1 | 6.04 |
| CHEMBL3126865 | — | — | 1 | 5.96 |
| CHEMBL3126899 | — | — | 1 | 5.89 |
| CHEMBL3127064 | — | — | 1 | 5.86 |
| CHEMBL3127066 | — | — | 1 | 5.55 |
| CHEMBL3127050 | — | — | 1 | 5.49 |
| CHEMBL3126896 | — | — | 1 | 5.48 |
| CHEMBL3127068 | — | — | 1 | 5.46 |
| CHEMBL3126895 | — | — | 1 | 5.30 |
| CHEMBL3126911 | — | — | 1 | 5.26 |
| CHEMBL3127067 | — | — | 1 | 5.21 |
| CHEMBL3127057 | — | — | 1 | 5.11 |
| CHEMBL3126874 | — | — | 1 | 4.90 |
| CHEMBL3127046 | — | — | 1 | 4.88 |
| CHEMBL3126880 | — | — | 1 | 4.84 |
| CHEMBL3127048 | — | — | 1 | 4.83 |
| CHEMBL3126900 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1814767 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1269812 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3126907 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3127055 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3127056 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3126908 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3126914 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3127049 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3126905 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3127065 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3127047 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3126906 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3126898 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3126865 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL3126899 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3127064 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3127066 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL3127050 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL3126896 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3127068 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL3126895 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL3126911 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL3127067 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3127057 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL3126874 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3127046 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL3126880 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3127048 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3126900 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3127058 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3126871 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL3127044 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3126875 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3126879 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3126876 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL319177 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126902 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126909 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126915 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3124960 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127045 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126881 | — | IC50 | > | 20000.0 | nM | - |