Assay Detail
Functional
CHEMBL3129238
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Cytostatic activity against human K562 cells after 72 hrs by MTT assay
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 82 | 6.09 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269812 | — | — | 1 | 8.00 |
| CHEMBL3127055 | — | — | 1 | 7.52 |
| CHEMBL1814768 | — | — | 1 | 7.52 |
| CHEMBL1814767 | — | — | 1 | 7.40 |
| CHEMBL3127049 | — | — | 1 | 7.40 |
| CHEMBL3126908 | — | — | 1 | 7.40 |
| CHEMBL3127065 | — | — | 1 | 7.22 |
| CHEMBL3127050 | — | — | 1 | 7.22 |
| CHEMBL3127067 | — | — | 1 | 7.16 |
| CHEMBL3126907 | — | — | 1 | 7.16 |
| CHEMBL3127068 | — | — | 1 | 7.05 |
| CHEMBL3126905 | — | — | 1 | 6.96 |
| CHEMBL3126899 | — | — | 1 | 6.82 |
| CHEMBL3127066 | — | — | 1 | 6.72 |
| CHEMBL3127058 | — | — | 1 | 6.66 |
| CHEMBL3127047 | — | — | 1 | 6.52 |
| CHEMBL3126911 | — | — | 1 | 6.50 |
| CHEMBL3127052 | — | — | 1 | 6.35 |
| CHEMBL3126902 | — | — | 1 | 6.28 |
| CHEMBL3126900 | — | — | 1 | 5.81 |
| CHEMBL3126865 | — | — | 1 | 5.29 |
| CHEMBL3126906 | — | — | 1 | 5.28 |
| CHEMBL3126914 | — | — | 1 | 5.16 |
| CHEMBL3127057 | — | — | 1 | 4.98 |
| CHEMBL3127051 | — | — | 1 | 4.94 |
| CHEMBL3126880 | — | — | 1 | 4.90 |
| CHEMBL3126871 | — | — | 1 | 4.84 |
| CHEMBL3126879 | — | — | 1 | 4.81 |
| CHEMBL3126895 | — | — | 1 | 4.80 |
| CHEMBL3127054 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269812 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3127055 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1814768 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1814767 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3127049 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3126908 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3127065 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3127050 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3127067 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3126907 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3127068 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3126905 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3126899 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3127066 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3127058 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3127047 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3126911 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3127052 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3126902 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3126900 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3126865 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL3126906 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL3126914 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL3127057 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3127051 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3126880 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3126871 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3126879 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL3126895 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3127054 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3126915 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3126889 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3126874 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL3126913 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3127046 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL3127061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127064 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126898 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126901 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126909 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126910 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126912 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127044 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3124960 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126881 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3126882 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3127063 | — | IC50 | > | 20000.0 | nM | - |