Assay Detail
Functional
CHEMBL3129374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as increase in intracellular cAMP accumulation after 30 mins by time-resolved fluorescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 8.80 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128199 | — | — | 1 | 10.40 |
| CHEMBL3128200 | — | — | 1 | 9.89 |
| CHEMBL3128194 | — | — | 1 | 9.82 |
| CHEMBL3128198 | — | — | 1 | 9.82 |
| CHEMBL3128189 | — | — | 1 | 9.74 |
| CHEMBL3128196 | — | — | 1 | 9.68 |
| CHEMBL3128201 | — | — | 1 | 9.43 |
| CHEMBL3128179 | — | — | 1 | 9.32 |
| CHEMBL3128177 | — | — | 1 | 9.19 |
| CHEMBL3128190 | — | — | 1 | 9.17 |
| CHEMBL3128191 | — | — | 1 | 9.08 |
| CHEMBL3128192 | — | — | 1 | 9.06 |
| CHEMBL1684585 | — | — | 1 | 9.01 |
| CHEMBL3128180 | — | — | 1 | 8.94 |
| CHEMBL3128178 | — | — | 1 | 8.87 |
| CHEMBL3128193 | — | — | 1 | 8.80 |
| CHEMBL3128197 | — | — | 1 | 8.73 |
| CHEMBL3128181 | — | — | 1 | 8.71 |
| CHEMBL3128188 | — | — | 1 | 8.43 |
| CHEMBL3128185 | — | — | 1 | 8.06 |
| CHEMBL3128183 | — | — | 1 | 7.91 |
| CHEMBL3128182 | — | — | 1 | 7.87 |
| CHEMBL3128187 | — | — | 1 | 7.78 |
| CHEMBL3128195 | — | — | 1 | 7.36 |
| CHEMBL3128186 | — | — | 1 | 7.12 |
| CHEMBL3128184 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128199 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3128200 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3128194 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3128198 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3128189 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3128196 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3128201 | — | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL3128179 | — | EC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3128177 | — | EC50 | = | 0.64 | nM | 9.19 |
| CHEMBL3128190 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL3128191 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL3128192 | — | EC50 | = | 0.88 | nM | 9.06 |
| CHEMBL1684585 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3128180 | — | EC50 | = | 1.15 | nM | 8.94 |
| CHEMBL3128178 | — | EC50 | = | 1.36 | nM | 8.87 |
| CHEMBL3128193 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3128197 | — | EC50 | = | 1.86 | nM | 8.73 |
| CHEMBL3128181 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL3128188 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3128185 | — | EC50 | = | 8.78 | nM | 8.06 |
| CHEMBL3128183 | — | EC50 | = | 12.4 | nM | 7.91 |
| CHEMBL3128182 | — | EC50 | = | 13.6 | nM | 7.87 |
| CHEMBL3128187 | — | EC50 | = | 16.7 | nM | 7.78 |
| CHEMBL3128195 | — | EC50 | = | 44.2 | nM | 7.36 |
| CHEMBL3128186 | — | EC50 | = | 76.7 | nM | 7.12 |
| CHEMBL3128184 | — | EC50 | = | 186.0 | nM | 6.73 |