Assay Detail
Functional
CHEMBL3129453
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Agonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilization
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110670 | VABICASERIN | 2.0 | 1 | 8.10 |
| CHEMBL1628670 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110670 | VABICASERIN | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1628670 | — | EC50 | = | 8.0 | nM | 8.10 |