Assay Detail
Binding
CHEMBL3129538
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Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.50 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.22 |
| CHEMBL3125544 | — | — | 1 | 7.68 |
| CHEMBL3125542 | — | — | 1 | 7.61 |
| CHEMBL3125543 | — | — | 1 | 7.60 |
| CHEMBL1545298 | — | — | 1 | 7.55 |
| CHEMBL1470455 | — | — | 1 | 7.55 |
| CHEMBL3125555 | — | — | 1 | 7.38 |
| CHEMBL3125563 | — | — | 1 | 7.12 |
| CHEMBL3125561 | — | — | 1 | 7.03 |
| CHEMBL3125564 | — | — | 1 | 6.82 |
| CHEMBL3125562 | — | — | 1 | 6.68 |
| CHEMBL3125554 | — | — | 1 | 6.62 |
| CHEMBL3125553 | — | — | 1 | 6.62 |
| CHEMBL3125556 | — | — | 1 | 6.60 |
| CHEMBL415079 | — | — | 1 | 6.36 |
| CHEMBL3125560 | — | — | 1 | 6.24 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.20 |
| CHEMBL3125559 | — | — | 1 | 6.15 |
| CHEMBL3125551 | — | — | 1 | 6.01 |
| CHEMBL3125547 | — | — | 1 | 5.88 |
| CHEMBL1450780 | — | — | 1 | 5.75 |
| CHEMBL3125552 | — | — | 1 | 5.70 |
| CHEMBL3125545 | — | — | 1 | 5.60 |
| CHEMBL3125549 | — | — | 1 | 5.59 |
| CHEMBL3125546 | — | — | 1 | 5.57 |
| CHEMBL3125548 | — | — | 1 | 5.56 |
| CHEMBL1603618 | — | — | 1 | 5.54 |
| CHEMBL3125550 | — | — | 1 | 4.87 |
| CHEMBL131790 | — | — | 1 | - |
| CHEMBL3125557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3125544 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL3125542 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL3125543 | — | Ki | = | 25.1 | nM | 7.60 |
| CHEMBL1545298 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL1470455 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL3125555 | — | Ki | = | 41.9 | nM | 7.38 |
| CHEMBL3125563 | — | Ki | = | 76.5 | nM | 7.12 |
| CHEMBL3125561 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL3125564 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3125562 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3125554 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3125553 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3125556 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL415079 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3125560 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL310671 | SACCHARIN | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL3125559 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL3125551 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL3125547 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL1450780 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL3125552 | — | Ki | = | 2010.0 | nM | 5.70 |
| CHEMBL3125545 | — | Ki | = | 2520.0 | nM | 5.60 |
| CHEMBL3125549 | — | Ki | = | 2540.0 | nM | 5.59 |
| CHEMBL3125546 | — | Ki | = | 2690.0 | nM | 5.57 |
| CHEMBL3125548 | — | Ki | = | 2760.0 | nM | 5.56 |
| CHEMBL1603618 | — | Ki | = | 2910.0 | nM | 5.54 |
| CHEMBL3125550 | — | Ki | = | 13410.0 | nM | 4.87 |
| CHEMBL131790 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3125557 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3125558 | — | Ki | > | 50000.0 | nM | - |