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Assay Detail

CHEMBL3129686

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Binding
Inhibition of Pseudomonas aeruginosa His-6-tagged PqsD expressed in Escherichia coli BL21 (lambdaDE3) using anthraniloyl-CoA/beta-ketodecanoic acid as substrate by LC-MS/MS analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections.
Hinsberger S, de Jong JC, Groh M, Haupenthal J, Hartmann RW.
Eur J Med Chem (2014) 76 : 343 -351
PubMed 24589489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 5.23 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3127038 1 5.89
CHEMBL3127034 1 5.89
CHEMBL2440280 1 5.50
CHEMBL2440282 1 5.50
CHEMBL2440267 1 5.48
CHEMBL2440270 1 5.47
CHEMBL2440274 1 5.42
CHEMBL2440271 1 5.40
CHEMBL2440266 1 5.38
CHEMBL2440283 1 5.36
CHEMBL2440269 1 5.31
CHEMBL2440284 1 5.30
CHEMBL2440261 1 5.30
CHEMBL2440281 1 5.29
CHEMBL3127027 1 5.28
CHEMBL2440273 1 5.24
CHEMBL2440260 1 5.22
CHEMBL2440272 1 5.21
CHEMBL175848 1 5.18
CHEMBL2440258 1 5.18
CHEMBL2440259 1 5.11
CHEMBL2440268 1 5.07
CHEMBL1713172 1 5.06
CHEMBL3127030 1 5.01
CHEMBL2440277 1 4.82
CHEMBL3127029 1 4.80
CHEMBL2440276 1 4.74
CHEMBL3127028 1 4.71
CHEMBL3127025 1 4.49
CHEMBL3127024 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3127038 IC50 = 1300.0 nM 5.89
CHEMBL3127034 IC50 = 1300.0 nM 5.89
CHEMBL2440280 IC50 = 3200.0 nM 5.50
CHEMBL2440282 IC50 = 3200.0 nM 5.50
CHEMBL2440267 IC50 = 3300.0 nM 5.48
CHEMBL2440270 IC50 = 3400.0 nM 5.47
CHEMBL2440274 IC50 = 3800.0 nM 5.42
CHEMBL2440271 IC50 = 4000.0 nM 5.40
CHEMBL2440266 IC50 = 4200.0 nM 5.38
CHEMBL2440283 IC50 = 4400.0 nM 5.36
CHEMBL2440269 IC50 = 4900.0 nM 5.31
CHEMBL2440284 IC50 = 5000.0 nM 5.30
CHEMBL2440261 IC50 = 5000.0 nM 5.30
CHEMBL2440281 IC50 = 5100.0 nM 5.29
CHEMBL3127027 IC50 = 5200.0 nM 5.28
CHEMBL2440273 IC50 = 5700.0 nM 5.24
CHEMBL2440260 IC50 = 6000.0 nM 5.22
CHEMBL2440272 IC50 = 6200.0 nM 5.21
CHEMBL2440258 IC50 = 6600.0 nM 5.18
CHEMBL175848 IC50 = 6600.0 nM 5.18
CHEMBL2440259 IC50 = 7700.0 nM 5.11
CHEMBL2440268 IC50 = 8600.0 nM 5.07
CHEMBL1713172 IC50 = 8700.0 nM 5.06
CHEMBL3127030 IC50 = 9800.0 nM 5.01
CHEMBL2440277 IC50 = 15200.0 nM 4.82
CHEMBL3127029 IC50 = 15700.0 nM 4.80
CHEMBL2440276 IC50 = 18200.0 nM 4.74
CHEMBL3127028 IC50 = 19500.0 nM 4.71
CHEMBL3127025 IC50 = 32600.0 nM 4.49
CHEMBL3127024 IC50 - -
CHEMBL3127035 IC50 - -
CHEMBL3127036 IC50 - -
CHEMBL3127037 IC50 - -
CHEMBL198666 IC50 - -
CHEMBL2440265 IC50 - -