Assay Detail
Binding
CHEMBL3129688
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Inhibition of Escherichia coli RNAP assessed as incorporation of [5,6-3H]UTP preincubated for 10 mins followed by DNA template and ATP, CTP, GTP, UTP, [5,6-3H]UTP addition measured after 10 mins by scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.61 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3127032 | — | — | 1 | 5.05 |
| CHEMBL3127030 | — | — | 1 | 5.00 |
| CHEMBL3127031 | — | — | 1 | 4.89 |
| CHEMBL3127034 | — | — | 1 | 4.46 |
| CHEMBL3127038 | — | — | 1 | 4.13 |
| CHEMBL2413673 | — | — | 1 | 4.11 |
| CHEMBL3127029 | — | — | 1 | - |
| CHEMBL3127025 | — | — | 1 | - |
| CHEMBL3127035 | — | — | 1 | - |
| CHEMBL3127036 | — | — | 1 | - |
| CHEMBL3127037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3127032 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3127030 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3127031 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3127034 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3127038 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL2413673 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL3127029 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL3127025 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL3127035 | — | IC50 | - | — | - | |
| CHEMBL3127036 | — | IC50 | - | — | - | |
| CHEMBL3127037 | — | IC50 | - | — | - |