Assay Detail

CHEMBL3130253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 4 days by luciferase reporter gene assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Hepatitis C virus (CHEMBL379) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Hepatitis C virus (CHEMBL379) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Cell Type	Huh-7
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

DeGoey DA, Randolph JT, Liu D, Pratt J, Hutchins C, Donner P, Krueger AC, Matulenko M, Patel S, Motter CE, Nelson L, Keddy R, Tufano M, Caspi DD, Krishnan P, Mistry N, Koev G, Reisch TJ, Mondal R, Pilot-Matias T, Gao Y, Beno DW, Maring CJ, Molla A, Dumas E, Campbell A, Williams L, Collins C, Wagner R, Kati WM.
J Med Chem (2014) 57 : 2047 -2057
PubMed 24400777 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	10.91	10.91

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3127326	OMBITASVIR	4.0	1	10.91

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3127326	OMBITASVIR	EC50	=	0.0124	nM	10.91