Assay Detail
Binding
CHEMBL3130350
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Inhibition of transthyretin V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of sodium acetate-mediated aggregation preincubated for 30 mins followed by sodium acetate addition measured after 96 hrs by thioflavin T assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Crystal structures of human transthyretin complexed with glabridin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.06 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.20 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.19 |
| CHEMBL480477 | GLABRIDIN | — | 1 | 5.19 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.11 |
| CHEMBL3127843 | — | — | 1 | 4.89 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL480477 | GLABRIDIN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL44 | GENISTEIN | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3127843 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 16000.0 | nM | 4.80 |