Assay Detail
Binding
CHEMBL3130754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method
21
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.61 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.89 |
| CHEMBL3127978 | — | — | 2 | 7.08 |
| CHEMBL3127966 | — | — | 1 | 7.00 |
| CHEMBL3127975 | — | — | 1 | 6.89 |
| CHEMBL3127968 | — | — | 2 | 6.85 |
| CHEMBL3127977 | — | — | 2 | 6.85 |
| CHEMBL3127967 | — | — | 2 | 6.72 |
| CHEMBL3127976 | — | — | 1 | 6.62 |
| CHEMBL3127974 | — | — | 1 | 6.57 |
| CHEMBL3127970 | — | — | 1 | 6.57 |
| CHEMBL1929421 | — | — | 1 | 6.46 |
| CHEMBL3127971 | — | — | 1 | 6.40 |
| CHEMBL3124971 | — | — | 2 | 4.82 |
| CHEMBL3127973 | — | — | 1 | - |
| CHEMBL3127972 | — | — | 1 | - |
| CHEMBL3127969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3127978 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3127978 | — | IC50 | = | 83.95 | nM | 7.08 |
| CHEMBL3127966 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3127975 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3127968 | — | IC50 | = | 139.96 | nM | 6.85 |
| CHEMBL3127977 | — | IC50 | = | 139.96 | nM | 6.85 |
| CHEMBL3127977 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3127968 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3127967 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3127967 | — | IC50 | = | 190.11 | nM | 6.72 |
| CHEMBL3127976 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3127974 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3127970 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1929421 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3127971 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3124971 | — | IC50 | = | 15205.48 | nM | 4.82 |
| CHEMBL3124971 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3127973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127969 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127972 | — | IC50 | > | 100000.0 | nM | - |