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Assay Detail

CHEMBL3131096

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of binding of wild type mBIMBH3 peptide to mouse adenosine A1 receptor by surface plasmon resonance competition experiment
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A1 (CHEMBL3688)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.
Brady RM, Vom A, Roy MJ, Toovey N, Smith BJ, Moss RM, Hatzis E, Huang DC, Parisot JP, Yang H, Street IP, Colman PM, Czabotar PE, Baell JB, Lessene G.
J Med Chem (2014) 57 : 1323 -1343
PubMed 24456288 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.85 4.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371861 1 4.85
CHEMBL3125475 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371861 IC50 = 14200.0 nM 4.85
CHEMBL3125475 IC50 > 25000.0 nM -