Assay Detail
Binding
CHEMBL3131100
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Inhibition of binding of wild type mBIMBH3 peptide to human Bcl-XL delta C24 mutant by surface plasmon resonance competition experiment
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.04 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371861 | — | — | 1 | 6.71 |
| CHEMBL3125475 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371861 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3125475 | — | IC50 | = | 4400.0 | nM | 5.36 |