Assay Detail
Binding
CHEMBL3131196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK3 alpha/beta in pig brain using YRRAAVPPSPSLSRHSSPHQpSEDEEE as substrate by scintillation counting in presence of [gamma-33P]ATP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.91 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409450 | 6BIO | — | 1 | 8.30 |
| CHEMBL100714 | — | — | 1 | 5.52 |
| CHEMBL1719330 | — | — | 1 | - |
| CHEMBL1277433 | — | — | 1 | - |
| CHEMBL301018 | — | — | 1 | - |
| CHEMBL1761927 | — | — | 1 | - |
| CHEMBL1191611 | — | — | 1 | - |
| CHEMBL3127769 | — | — | 1 | - |
| CHEMBL3127768 | — | — | 1 | - |
| CHEMBL316064 | — | — | 1 | - |
| CHEMBL94191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409450 | 6BIO | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL100714 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1719330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1277433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL301018 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1191611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL316064 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL94191 | — | IC50 | > | 10000.0 | nM | - |