Assay Detail
Binding
CHEMBL3131197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.08 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409450 | 6BIO | — | 1 | 7.08 |
| CHEMBL1719330 | — | — | 1 | - |
| CHEMBL1277433 | — | — | 1 | - |
| CHEMBL301018 | — | — | 1 | - |
| CHEMBL1761927 | — | — | 1 | - |
| CHEMBL1191611 | — | — | 1 | - |
| CHEMBL100714 | — | — | 1 | - |
| CHEMBL3127769 | — | — | 1 | - |
| CHEMBL3127768 | — | — | 1 | - |
| CHEMBL316064 | — | — | 1 | - |
| CHEMBL94191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409450 | 6BIO | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1719330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1277433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL301018 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1191611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL100714 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127768 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL316064 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL94191 | — | IC50 | > | 10000.0 | nM | - |