Assay Detail
Binding
CHEMBL3131492
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Inhibition of Electric eel AChE assessed as amount of thiocholine released using acetylthiocholine iodide as substrate after 6 mins by Ellman's method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.31 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.05 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.62 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 4.94 |
| CHEMBL3125442 | — | — | 1 | 4.93 |
| CHEMBL3125443 | — | — | 1 | 4.90 |
| CHEMBL58579 | — | — | 1 | 4.90 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL416526 | BUFOTENINE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3125442 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3125443 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL58579 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL7257 | MEBUFOTENIN | IC50 | = | 14000.0 | nM | 4.85 |